How to determine the starting dose of Viagra?
For most men, the recommended initial dose of Viagra is 50 mg but depending on your individual tolerance/health issues, the dosage may be increased up to 100 mg or reduced to 25 mg.
The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.g., cirrhosis, 80%), severe renal impairment (creatinine clearance <30 mL/min, 100%), and concomitant use of potent cytochrome P450 3A4 inhibitors [ketoconazole, itraconazole, erythromycin (182%), saquinavir (210%)]. Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.
What happens if I miss a dose?
Sildenafil is used as needed, so you are not likely to miss a dose.
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